Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38. | PubMed
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Wu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641. | PubMed
NK cell cartoon
Thank you Pedromics for the cartoon based on our recent paper in ‘Nature Immunology’ – “Metabolic Reprogramming of Natural Killer cells in obesity limits anti-tumor responses. Looks great!
See it here: https://lynch-lab.org/wp-content/uploads/2018/12/NKCartoon.pdf
Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses
Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology. | PubMed