Entries by awp-admin

Convergence of Systemic and Cellular Immunometabolism

Lean adipose tissue is characterized by an enrichment of anti-inflammatory immune cells whose phenotype is driven by metabolic changes induced by the adipose microenvironment. Adipose tissue lipids bind to PPARg in regulatory T cells and alternatively activated (anti-inflammatory) macrophages and promote a regulatory program associated with oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO). Overfeeding […]

Innate immune cells in adipose tissue

The immune system in adipose tissue is largely under-appreciated, yet adipose tissue contains an incredibly unique and substantial immune system. Adipose tissue covers much of the body, and can account for 50% of body mass in obesity. Each adipose depot in humans and mice has its own substantial immune system with collectively more lymphocytes than […]

Adipose iNKT cells

Obesity has reached epidemic proportions globally. At least 2.8 million people die each year as a result of being overweight or obese, the biggest burden being obesity-related diseases. It is now clear that inflammation, particularly in adipose tissue itself, interferes with insulin signaling and is an underlying cause or contributor to many of these diseases, […]

Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity

S. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. (2017) Immunity 21, 46:273-286. | PubMed

Immunity publication, commentary by Emilie Narni-Mancinelli and Eric Vivier

Innate lymphoid cells (ILCs) residing in adipose tissue participate in the pathogenesis of obesity, but their contribution toward adipose tissue homeostasis in the lean state is unclear. Boulenouar et al. (2017) now report that heterogenous type 1 ILCs in adipose tissues regulate macrophage homeostasis through cytotoxicity. Click here to view article in Cell. Click here to download.

Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue.

L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature […]

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity

E. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed