Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative […]
About Lydia Lynch
This author has yet to write their bio.Meanwhile lets just say that we are proud Lydia Lynch contributed a whooping 24 entries.
Entries by Lydia Lynch
Room 632 is home to a bunch of wonderful female scientists from all corners of the globe.
Lydia was the recipient of the 2020 Department of Medicine Early Career Mentoring Award. Thanks for all your support Lydia!
Nelson M. LaMarche Harry Kane Ayano C. Kohlgruber Han Dong Lydia Lynch 9 Michael B. Brenner 9, 10 | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30256-4
Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1 NEG cells almost exclusively […]
The Lynch Lab is now utilizing in-house single cell RNA-Seq analysis to drive and inform a number of different exciting projects, including identifying global changes in the immune system associated with obesity and weight loss, providing insights into innate T cell biology and innate T cell cellular metabolism, investigating the phenotype and functions of the […]
Harry Kane and Lydia Lynch. Innate Immune Control of Adipose Tissue Homeostasis. Trends in Immunology. 2019 August. | PubMed
Roisin Loftus was recently awarded the Irish Cancer Society 2019 biomedical research fellowship to advance obesity-associated cancer research in Ireland. Recent research from the Lynch lab has shown that obesity blocks the normal functions of Natural Killer cells, which may contribute to the increased risk of cancer in obesity. The focus of Roisin’s ICS fellowship […]
A recent publication by the Lynch Lab on how cancer-fighting natural killer cells are inactivated during obesity has been picked up by several news outlets! Well done guys! Here are a few links below: https://www.independent.ie/irish-news/health/trinity-college-scientists-discover-new-link-between-obesity-and-cancer-37519901.html https://www.irishmirror.ie/news/irish-news/health-news/irish-scientists-trinity-college-dublin-13578617 https://www.thejournal.ie/cancer-obesity-research-trinity-college-dublin-4335526-Nov2018/ https://www.irishexaminer.com/breakingnews/views/ourview/fighting-obesity-and-cancer–kitchen-class-884929.html