Immune and non-immune functions of adipose tissue leukocytes
Trim, W. V., & Lynch, L. (2022). Immune and non-immune functions of adipose tissue leukocytes. Nature reviews. Immunology, 22(6), 371–386. | https://pubmed.ncbi.nlm.nih.gov/34741167/
Entries by Lydia Lynch
Diet, lipids, and antitumor immunity
Prendeville, H., Lynch, L., 2022. Diet, lipids, and antitumor immunity. Cellular & Molecular Immunology, 19, pp. 432–444 | Pubmed
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector […]
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative […]
International Day of Women and Girls in Science
Room 632 is home to a bunch of wonderful female scientists from all corners of the globe.
Lydia receives the Early Career Mentoring Award
Lydia was the recipient of the 2020 Department of Medicine Early Career Mentoring Award. Thanks for all your support Lydia!
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis
LaMarche, N.M., Kane, H., Kohlgruber, A.C., Dong, H., Lynch, L. and Brenner, M.B., 2020. Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis. Cell Metabolism, 32(2), pp.243-258. | PubMed
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis
Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1 NEG cells almost exclusively […]
Single cell RNA-Seq
The Lynch Lab is now utilizing in-house single cell RNA-Seq analysis to drive and inform a number of different exciting projects, including identifying global changes in the immune system associated with obesity and weight loss, providing insights into innate T cell biology and innate T cell cellular metabolism, investigating the phenotype and functions of the […]
Innate Immune Control of Adipose Tissue Homeostasis
Kane, H. and Lynch, L., 2019. Innate immune control of adipose tissue homeostasis. Trends in immunology, 40(9), pp.857-872. | PubMed