Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector […]
About Lydia Lynch
This author has not written his bio yet.
But we are proud to say that Lydia Lynch contributed 25 entries already.
Entries by Lydia Lynch
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative […]
Room 632 is home to a bunch of wonderful female scientists from all corners of the globe.
Lydia was the recipient of the 2020 Department of Medicine Early Career Mentoring Award. Thanks for all your support Lydia!
LaMarche, N.M., Kane, H., Kohlgruber, A.C., Dong, H., Lynch, L. and Brenner, M.B., 2020. Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis. Cell Metabolism, 32(2), pp.243-258. | PubMed
Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1 NEG cells almost exclusively […]
The Lynch Lab is now utilizing in-house single cell RNA-Seq analysis to drive and inform a number of different exciting projects, including identifying global changes in the immune system associated with obesity and weight loss, providing insights into innate T cell biology and innate T cell cellular metabolism, investigating the phenotype and functions of the […]
Kane, H. and Lynch, L., 2019. Innate immune control of adipose tissue homeostasis. Trends in immunology, 40(9), pp.857-872. | PubMed
Roisin Loftus was recently awarded the Irish Cancer Society 2019 biomedical research fellowship to advance obesity-associated cancer research in Ireland. Recent research from the Lynch lab has shown that obesity blocks the normal functions of Natural Killer cells, which may contribute to the increased risk of cancer in obesity. The focus of Roisin’s ICS fellowship […]
A recent publication by the Lynch Lab on how cancer-fighting natural killer cells are inactivated during obesity has been picked up by several news outlets! Well done guys! Here are a few links below: https://www.independent.ie/irish-news/health/trinity-college-scientists-discover-new-link-between-obesity-and-cancer-37519901.html https://www.irishmirror.ie/news/irish-news/health-news/irish-scientists-trinity-college-dublin-13578617 https://www.thejournal.ie/cancer-obesity-research-trinity-college-dublin-4335526-Nov2018/ https://www.irishexaminer.com/breakingnews/views/ourview/fighting-obesity-and-cancer–kitchen-class-884929.html