Entries by Lydia Lynch

Nelson M. LaMarche Harry Kane Ayano C. Kohlgruber Han Dong Lydia Lynch 9 Michael B. Brenner 9, 10 | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30256-4

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1 NEG cells almost exclusively […]

Single cell RNA-Seq

The Lynch Lab is now utilizing in-house single cell RNA-Seq analysis to drive and inform a number of different exciting projects, including identifying global changes in the immune system associated with obesity and weight loss, providing insights into innate T cell biology and innate T cell cellular metabolism, investigating the phenotype and functions of the […]

Roisin is awarded the Irish Cancer Society 2019 biomedical research fellowship!

Roisin Loftus was recently awarded the Irish Cancer Society 2019 biomedical research fellowship to advance obesity-associated cancer research in Ireland. Recent research from the Lynch lab has shown that obesity blocks the normal functions of Natural Killer cells, which may contribute to the increased risk of cancer in obesity. The focus of Roisin’s ICS fellowship […]

Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses

A recent publication by the Lynch Lab on how cancer-fighting natural killer cells are inactivated during obesity has been picked up by several news outlets! Well done guys! Here are a few links below: https://www.independent.ie/irish-news/health/trinity-college-scientists-discover-new-link-between-obesity-and-cancer-37519901.html https://www.irishmirror.ie/news/irish-news/health-news/irish-scientists-trinity-college-dublin-13578617 https://www.thejournal.ie/cancer-obesity-research-trinity-college-dublin-4335526-Nov2018/ https://www.irishexaminer.com/breakingnews/views/ourview/fighting-obesity-and-cancer–kitchen-class-884929.html

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.

Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at […]

NK cell cartoon

Thank you Pedromics for the cartoon based on our recent paper in ‘Nature Immunology’ – “Metabolic Reprogramming of Natural Killer cells in obesity limits anti-tumor responses. Looks great! See it here: https://lynch-lab.org/wp-content/uploads/2018/12/NKCartoon.pdf