Entries by Lydia Lynch

Claire awarded CRI Irvington Postdoctoral Fellowship

Congratulations to Claire who was awarded the CRI Irvington Postdoctoral Fellowship. Her research seeks to clarify how dietary factors, particularly high-fat and high-cholesterol diets, contribute to tumor growth and immune responses, potentially offering insights into cancer prevention and treatment through dietary interventions.

Sven Gard’s Scholarship award for Katie Healy

A huge honour for Kerry native Katie Healy as she is granted the Sven Gard’s scholarship award. This is awarded to the best dissertation in virology in the Karolinska Institute. Her dissertation was titled the ‘Potential role of MAIT cells in cancer immunotherapy and viral infection’.

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector […]

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative […]

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the case is unclear. Here, using single-cell RNA sequencing, we found several adipose iNKT clusters, which we grouped into two functional populations based on NK1.1 expression. NK1.1 NEG cells almost exclusively […]

Single cell RNA-Seq

The Lynch Lab is now utilizing in-house single cell RNA-Seq analysis to drive and inform a number of different exciting projects, including identifying global changes in the immune system associated with obesity and weight loss, providing insights into innate T cell biology and innate T cell cellular metabolism, investigating the phenotype and functions of the […]