Roisin Loftus was recently awarded the Irish Cancer Society 2019 biomedical research fellowship to advance obesity-associated cancer research in Ireland. Recent research from the Lynch lab has shown that obesity blocks the normal functions of Natural Killer cells, which may contribute to the increased risk of cancer in obesity. The focus of Roisin’s ICS fellowship […]
A recent publication by the Lynch Lab on how cancer-fighting natural killer cells are inactivated during obesity has been picked up by several news outlets! Well done guys! Here are a few links below: https://www.independent.ie/irish-news/health/trinity-college-scientists-discover-new-link-between-obesity-and-cancer-37519901.html https://www.irishmirror.ie/news/irish-news/health-news/irish-scientists-trinity-college-dublin-13578617 https://www.thejournal.ie/cancer-obesity-research-trinity-college-dublin-4335526-Nov2018/ https://www.irishexaminer.com/breakingnews/views/ourview/fighting-obesity-and-cancer–kitchen-class-884929.html
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at […]
Wu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a […]
Thank you Pedromics for the cartoon based on our recent paper in ‘Nature Immunology’ – “Metabolic Reprogramming of Natural Killer cells in obesity limits anti-tumor responses. Looks great! See it here: https://lynch-lab.org/wp-content/uploads/2018/12/NKCartoon.pdf
Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature […]
Kohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1. | PubMed
Dyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity, 48(1), pp.9-11. | PubMed
LaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism, 27(3), pp.485-486. | PubMed