Innate Immune Control of Adipose Tissue Homeostasis
Harry Kane and Lydia Lynch. Innate Immune Control of Adipose Tissue Homeostasis. Trends in Immunology. 2019 August. | PubMed
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
/0 Comments/in Publications /by Lydia LynchHong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38. | PubMed
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
/0 Comments/in Publications /by Lydia LynchWu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641. | PubMed
Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses
/0 Comments/in Publications /by Lydia LynchXavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology. | PubMed
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
/0 Comments/in Publications /by Lydia LynchKohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1. | PubMed
New Job for NK Cells: Architects of the Tumor Microenvironment.
/0 Comments/in Publications /by Lydia LynchDyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity, 48(1), pp.9-11. | PubMed
Adipose Dendritic Cells Come Out of Hiding
/0 Comments/in Publications /by Lydia LynchLaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism, 27(3), pp.485-486. | PubMed
Cancer, obesity and immunometabolism – Connecting the dots.
/0 Comments/in Publications /by Lydia LynchDyck, L. and Lynch, L., 2018. Cancer, obesity and immunometabolism–Connecting the dots. Cancer letters, 417, pp.11-20. | PubMed
Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.
/0 Comments/in Publications /by Lydia LynchSK. Chang, A. Kohlgruber, F. Mizoguchi, M. Xavier, B. Wolf, K. Wei, P. Lee, L. Lynch, D.Duquette, V.Ceperuelo-Mallafre, A. Banks, M.B. Brenner. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal of Clinical Investigation, in press Sept 2017. | PubMed
A sympathetic-neuroendocrine adrenal reflex causes spinal cord injury-induced immunodeficiency.
/0 Comments/in Publications /by Lydia LynchPrüss, H., Tedeschi, A., Thiriot, A., Lynch, L., Loughhead, S.M., Stutte, S., Mazo, I.B., Kopp, M.A., Brommer, B., Blex, C. and Geurtz, L.C., 2017. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nature neuroscience, 20(11), p.1549. | PubMed