Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nature Immunology, 22(2), pp.179-192. | PubMed

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

LaMarche, N.M., Kane, H., Kohlgruber, A.C., Dong, H., Lynch, L. and Brenner, M.B., 2020. Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis. Cell Metabolism, 32(2), pp.243-258. | PubMed

Innate Immune Control of Adipose Tissue Homeostasis

Kane, H. and Lynch, L., 2019. Innate immune control of adipose tissue homeostasis. Trends in immunology, 40(9), pp.857-872. | PubMed

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.

Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38. | PubMed

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.

Wu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641. | PubMed

Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses

Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology. | PubMed

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Kohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1. | PubMed

New Job for NK Cells: Architects of the Tumor Microenvironment.

Dyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity48(1), pp.9-11.  | PubMed

Adipose Dendritic Cells Come Out of Hiding

LaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism27(3), pp.485-486. | PubMed

Cancer, obesity and immunometabolism – Connecting the dots.

Dyck, L. and Lynch, L., 2018. Cancer, obesity and immunometabolism–Connecting the dots. Cancer letters417, pp.11-20. | PubMed