Immune and non-immune functions of adipose tissue leukocytes
Trim, W. V., & Lynch, L. (2022). Immune and non-immune functions of adipose tissue leukocytes. Nature reviews. Immunology, 22(6), 371–386. | https://pubmed.ncbi.nlm.nih.gov/34741167/
Diet, lipids, and antitumor immunity
/0 Comments/in Publications /by Lydia LynchPrendeville, H., Lynch, L., 2022. Diet, lipids, and antitumor immunity. Cellular & Molecular Immunology, 19, pp. 432–444 | Pubmed
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
/0 Comments/in Publications /by Lydia LynchLopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nature Immunology, 22(2), pp.179-192. | PubMed
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis
/0 Comments/in Publications /by Lydia LynchLaMarche, N.M., Kane, H., Kohlgruber, A.C., Dong, H., Lynch, L. and Brenner, M.B., 2020. Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis. Cell Metabolism, 32(2), pp.243-258. | PubMed
Innate Immune Control of Adipose Tissue Homeostasis
/0 Comments/in Publications /by Lydia LynchKane, H. and Lynch, L., 2019. Innate immune control of adipose tissue homeostasis. Trends in immunology, 40(9), pp.857-872. | PubMed
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
/0 Comments/in Publications /by Lydia LynchHong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38. | PubMed
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
/0 Comments/in Publications /by Lydia LynchWu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641. | PubMed
Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses
/0 Comments/in Publications /by Lydia LynchXavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology. | PubMed
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
/0 Comments/in Publications /by Lydia LynchKohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1. | PubMed
New Job for NK Cells: Architects of the Tumor Microenvironment.
/0 Comments/in Publications /by Lydia LynchDyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity, 48(1), pp.9-11. | PubMed