Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity

S. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. (2017) Immunity 21, 46:273-286. PubMed

iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy

L. Lynch, A.E. Hogan, D. Duquette, C. Lester, A. Banks, K. LeClair, D. Cohen, A. Ghosh, B. Lu, M. Corrigan, D. Stevanovic, E. Maratos-Flier, D. Drucker, D. O’Shea, and M.B. Brenner. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metabolism, 2016; 24(3):510-519. | PubMed

Adipose Tissue at the nexus of immunometabolism

A. Kohngruber, N. La Marche, and L. Lynch. Adipose Tissue at the nexus of immunometabolism. Seminars in Immunology. 2016: 28(5):431-440.| PubMed

Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue.

L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology 2015;16(1):85-95. | PubMed

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity

E. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed

Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes

A. Kohngruber, and L. Lynch. Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes. Current Diabetes Reports, 2015:15(11):92. | PubMed

Surgical injury induces local and distant adipose tissue browning

A. Longchamp, M. Tao, A. Bartelt, K. Ding, L. Lynch, C. Hine, J. Corpataux, B.S. Kristal, J.R. Mitchell, and C.K. Ozaki. Surgical injury induces local and distant adipose tissue browning. Adipocyte, 2015;5(2):163-174. | PubMed

The transcriptional program of iNKT cells.

E.Y. Kim, L. Lynch, P.J. Brennan, N.R. Cohen, and M.B. Brenner. The transcriptional programs of iNKT cells. Review. Seminars in Immunology, 2015;27(1):26-32. | PubMed

The interplay between the immune system and adipocytes in metabolic control.

M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. | PubMed

Adipose invariant Natural Killer T cells

L. Lynch. Adipose invariant Natural Killer T cells. Review. Immunology, 2014;142(3):337-46. | PubMed