Adipose Dendritic Cells Come Out of Hiding
LaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism, 27(3), pp.485-486. | PubMed
Cancer, obesity and immunometabolism – Connecting the dots.
/0 Comments/in Publications /by Lydia LynchDyck, L. and Lynch, L., 2018. Cancer, obesity and immunometabolism–Connecting the dots. Cancer letters, 417, pp.11-20. | PubMed
Powered bybambora shipping
Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.
/0 Comments/in Publications /by Lydia LynchSK. Chang, A. Kohlgruber, F. Mizoguchi, M. Xavier, B. Wolf, K. Wei, P. Lee, L. Lynch, D.Duquette, V.Ceperuelo-Mallafre, A. Banks, M.B. Brenner. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal of Clinical Investigation, in press Sept 2017. | PubMed
A sympathetic-neuroendocrine adrenal reflex causes spinal cord injury-induced immunodeficiency.
/0 Comments/in Publications /by Lydia LynchPrüss, H., Tedeschi, A., Thiriot, A., Lynch, L., Loughhead, S.M., Stutte, S., Mazo, I.B., Kopp, M.A., Brommer, B., Blex, C. and Geurtz, L.C., 2017. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nature neuroscience, 20(11), p.1549. | PubMed
Srebp-controlled glucose metabolism is essential for NK cell functional responses.
/0 Comments/in Publications /by Lydia LynchAssmann, N., O’Brien, K.L., Donnelly, R.P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R.M., Heinrich, P., Oefner, P.J., Lynch, L., Gardiner, C.M. and Dettmer, K., 2017. Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nature immunology, 18(11), p.1197. | PubMed
Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity
/0 Comments/in Publications /by awp-adminS. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. (2017) Immunity 21, 46:273-286. | PubMed
iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy
/0 Comments/in Publications /by awp-adminL. Lynch, A.E. Hogan, D. Duquette, C. Lester, A. Banks, K. LeClair, D. Cohen, A. Ghosh, B. Lu, M. Corrigan, D. Stevanovic, E. Maratos-Flier, D. Drucker, D. O’Shea, and M.B. Brenner. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metabolism, 2016; 24(3):510-519. | PubMed
Adipose Tissue at the nexus of immunometabolism
/0 Comments/in Publications /by awp-adminA. Kohngruber, N. La Marche, and L. Lynch. Adipose Tissue at the nexus of immunometabolism. Seminars in Immunology. 2016: 28(5):431-440.| PubMed
Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue.
/0 Comments/in Publications /by awp-adminL. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology 2015;16(1):85-95. | PubMed
Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity
/0 Comments/in Publications /by awp-adminE. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed