Lydia Lynch received her B.Sc. degree in Cell Biology and Genetics from University College Dublin, Ireland. She received her PhD in Immunology in 2008 from University College Dublin, in the lab of Prof. Cliona O’Farrelly in St. Vincent’s University Hospital.
Lydia received a Newman Fellowship for her early post-doctoral studies with Prof. Donal O’Shea in St. Vincent’s University Hospital, Dublin. Here they established the Immunology and Obesity Lab, which coordinates international, collaborative, translational research in obesity and its complications. Lydia then received the prestigious UNESCO-L’Oreal International Women In Science Fellowship, where she moved to Harvard Medical School to study iNKT cells in adipose tissue in the lab of Mark Exley. In 2009, Lydia received an International Marie Curie Fellowship to continue her postdoctoral studies in immunometabolism, in the labs of Prof. Michael Brenner and Prof. Ulrich von Andrian in Harvard. In 2013, she became a junior faculty member at Brigham and Women’s Hospital and Harvard Medical School. In 2014, Lydia started her independent lab with a joint appointment between the Division of Endocrinology and the Division of Rheumatology, Allergy and Immunology, at Brigham and Women’s Hospital and Harvard Medical School.
Lydia’s lab is interested in the effects of obesity and diet on immune cell functions, particularly innate cells including iNKT cells, NK cells and T cells. The Lynch lab also studies the role of the immune system in the regulation of metabolism and body weight, particularly the local immune system in adipose tissue in mice and humans.
Project: Effects of obesity on the immune regulation of cancer
Science Interests: Cancer immunology and immunotherapy, immune checkpoints, immunometabolism
Interests/hobbies outside of science: Hockey, tag rugby, pub quizzes, traveling
Favourite Cell: CD8 T cell
Project: The focus of my research is to characterise the mechanisms by which obesity impairs Natural Killer cell metabolism and function. I am interested in the relationship between PPAR transcription factors and obesity in NK cell activation and hope to uncover how lipids suppress Natural Killer cell mTORC1 activity.
Science Interests: Immunometabolism, signal transduction, cytotoxic assays, flow cytometry.
Interests/hobbies outside of science: I love to travel, swim in the Irish Sea, hike in the Wicklow mountains and pump iron with my personal trainer Aaron
Favourite Cell: Natural Killer cells of course
Project: My research lies in identifying how the gamma delta T cells differ and how they each participate in the immune response. I am looking at their phenotypes, metabolism, and I am interested in their function in disease propagation and mitigation.
Science Interests: Anything related to immunology!
Interests/hobbies outside of science: I love hiking, painting and gardening…and cheese and wine (what can you do against your cultural heritage?!)
Favourite Cell: Gamma Delta T cells rock!
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Project: Harnessing gamma-delta T cells in anti-tumour immunity: By investigating the heterogeneity of innate lymphocytes in human tumours, this project hopes to identify the most useful subsets for cellular therapy and checkpoint targeting in cancer patients.
Interests/hobbies outside of science: When I’m not in the lab I enjoy travelling, reading, movies and sampling every craft beer and coffee made by mankind.
Favourite Cell: How can you choose just one innate lymphocyte, they all work so well together. NK cells and gamma delta T cells are a personal favourite though.
Senior Technician, Lab Manager, PhD student
Project: Why do we have Granzyme K?
Science Interests: All things fish! And imaging immune cells! With a degree in Marine Biology and a masters in zoology, Danielle studied Sex determination in response to Stress in Black Sea Bass (Centropristis striata).
Interests/hobbies outside of science: Outside of managing the lab, Danielle enjoys visiting aquariums all over the country, and crossfit challenges. Also art and making killer Halloween costumes!
Favourite cell: NK cells- bright and dims!
Role: My role is to help with the administration, finances, orderings, equipment set up and maintenance, sample collections and to aid researchers when needed. Making lab life run smoothly for all researchers involved is my main aim.
Background: Immunology, Bioinformatics. Experiences with financial accounts and TCD administration.
Interests/hobbies outside of science: Tennis, Floristry and Art (abstracts and animal portraits, facebook @tilleysfamilyart)
Favourite cell:Dendritic Cell
(Co-mentored with Michael Brenner)
Project: Adipose iNKT cells
Science Interests: Autoimmunity, immune regulation, innate-like T cells, immunometabolism
Interests/hobbies outside of science: When not in the lab, Nelson enjoys wine tasting, yoga, salsa dancing, and anything that has to do with dogs
Favourite Cell: iNKT cell of course, but the Treg is a close second
Project: iNKT cell metabolism and role of iNKT cells in adipose thermogenesis
Science Interests: Immunometabolism, Immunology
Interests/hobbies outside of science: Canoe Polo, gaming, jumpers and food (particularly cookies and pizza!)
Favourite Cell: iNKT cell is mandatory, but I have a soft spot for CD4+ T cells too.
Project: Throughout my PhD I’ll be investigating the effects of various lipid rich diets on anti-tumour immunity. Specifically, I hope to understand how lipids are used by tumour-infiltrating leukocytes, if they are stored intra-cellularly or used as a fuel source and whether this impacts their pro- or anti-tumourigenic functions.
Science Interests: Immunometabolism, cancer immunology, innate immunity, cell signalling.
Interests/hobbies outside of science: Music (violin), concerts, festivals, swimming and I’ve just joined the Trinity Hiking Society so I’ll see how that goes!
Favourite Cell: Tumour associated macrophages (TAMs) and NK cells.
Project: Understanding the role of innate lymphocytes in thermosensation, thermoregulation and thermogenesis.
Science Interests:Neuroscience, immunology and everything in between (Neuroimmunology).
Interests/hobbies outside of science: Karate, boxing, gaming, power-lifting, mixology, music- guitar, drums and saxophone player. Previous member of the band Thick as Thieves!
Favourite Cell: Is it cheating if I have three? Gamma delta T cells, TRMP8 Sensory Neurons and most recently Type 3 Innate Lymphoid cells (ILC3s)
Project: Targeting human gamma delta T cell metabolism for improved longevity and anti-cancer function in the tumor microenvironment.
Interests/hobbies outside of science: When Andy is not in the lab, he enjoys competing and teaching kickboxing Bouldering & Long Walks on the Beach. He also runs his own gym providing training for adults and children in Dublin Ireland.
Favourite Cell: MAIT cell
Current position: Co. P.I – National Children’s Research Centre, Ireland
Xavier Michelet, PhD
Project: Study of Natural Killer cell biology and dysfunction during obesity. My research focuses on deciphering the mechanisms by which a lipid rich environment impairs anti-tumor functions of NK cells.
Science Interests: My interest in cell biology brought me to study various applications including development, immunology and recently immunometabolsim. My research focuses on the study of the endo-lysosome pathway at the cellular level and how it impacts the whole organism. I am deeply interested in the lysosome biology that has proven to be more than the ‘cellular incinerator’ but involved in much broader functions such as antigen presentation, secretion, plasma membrane repair, signaling and metabolism. Using my cell biology and immunology skills, I wish to develop a novel niche, which investigates in detail the role of the lysosome and lysosomes related organelles in metabolic disease. The ability of the lysosome to sense nutrients and stress within the cell and to trigger key signaling pathways places it at the center of many research fields, particularly in metabolic disease.
Interests/hobbies outside of science: Xavier loves Travel, History, Woodworking, Star Wars, and daughter Eleanore!
Favourite Cell: Natural Killer cell and Dentritic Cells
Graduate Student (Co-mentored with Prof. Michael Brenner)
Project: Understanding the role of gamma delta T cells in adipose tissue biology
Science Interests: All things immunology!
Interests/hobbies outside of science: Outside of Immunology, Ayano enjoys hiking/backpacking, running, bread baking, teaching, labradoodles, and traveling!