Publications

Journal Articles
  1. S. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. Immunity In press, Feb 2017.

  2. L. Lynch, A.E. Hogan, D. Duquette, C. Lester, A. Banks, K. LeClair, D. Cohen, A. Ghosh, B. Lu, M. Corrigan, D. Stevanovic, E. Maratos-Flier, D. Drucker, D. O’Shea, and M.B. Brenner. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metabolism, 2016; 24(3):510-519. | PubMed

  3. A. Kohngruber, N. La Marche, and L. Lynch. Adipose Tissue at the nexus of immunometabolism. Seminars in Immunology. 2016: 28(5):431-440.| PubMed

  4. L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology 2015;16(1):85-95. | PubMed

  5. E. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed

  6. A. Kohngruber, and L. Lynch. Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes. Current Diabetes Reports, 2015:15(11):92. | PubMed

  7. A. Longchamp, M. Tao, A. Bartelt, K. Ding, L. Lynch, C. Hine, J. Corpataux, B.S. Kristal, J.R. Mitchell, and C.K. Ozaki. Surgical injury induces local and distant adipose tissue browning. Adipocyte, 2015;5(2):163-174. | PubMed

  8. E.Y. Kim, L. Lynch, P.J. Brennan, N.R. Cohen, and M.B. Brenner. The transcriptional programs of iNKT cells. Review. Seminars in Immunology, 2015;27(1):26-32. | PubMed

  9. M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. | PubMed

  10. L. Lynch. Adipose invariant Natural Killer T cells. Review. Immunology, 2014;142(3):337-46. | PubMed

  11. G.A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes 2014; 63(6):2037-50. | PubMed

  12. A.E. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetalogica 2014; 57(4):781-4. | PubMed

  13. L. Lynch, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Prodution. Immunity, 2012; 21;37(3):574-87. | PubMed

  14. L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, L. Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. American J Reproductive Immunology 2012; 67(1):9-16. | PubMed

  15. M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells Clin Immunol. 2011; 140(2):184-95. | PubMed

  16. J. O’Connell, L. Lynch, A.E. Hogan, T.J. Cawood, and D. O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. Journal of Clinical Endocrinology and Metabolism, 2012; 96: 680-684. | PubMed

  17. A.E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. Diabetalogica, 2011; 54(11):2745-2754. | PubMed

  18. A.E. Hogan, M.A. Corrigan, V . O’Reilly, G. Gaoatswe, J. O’Connell, D.G. Doherty, L. Lynch, and D. O’Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol, 2011; 40(3):229-35. | PubMed

  19. A.M. Tobin, L. Lynch, B. Kirby, and C. O’Farrelly. Natural killer cells in psoriasis. Review. J. Innate Immunity, 2011; 3(4):403-410. | PubMed

  20. D. O’Shea, T.J. Cawood, C. O’Farrelly, and L. Lynch. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. 2010; 25;5(1):e8660. | PubMed

  21. M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol, 2010; 40(3):682-687. | PubMed

  22. J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One, 2010; e9997. | PubMed

  23. A. O’Donovan, B.M. Hughes, G.M. Slavich, L. Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. Brain Behav Immun, 2010; 24(7):1074-7. | PubMed

  24. L. Lynch, D. O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. Eur. J. Immunology, 32009; 9(7):1893-1901. | PubMed

  25. L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? Obesity (Silver Spring) 2009; 17:601-605. | PubMed

  26. E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility. American Journal of Reproduction, 2008; 61:265-276. | PubMed

  27. L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? Human Reproduction, 2006; 22:919-26. | PubMed

  28. L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. Journal of Immunology, 2006; 176: 5199-5204. | PubMed

Book Chapters
  1. M.A. Exley, L. Lynch, M. Nowak. NKT Cells of Cancer Patients and How Models Can Inform Therapeutic Plans (2012) [chapter]. In: Natural Killer T cells. Balancing the Regulation of Tumor Immunity. Terabe M, Berzofsky JA, editors.