McIntyre, C. L., Temesgen, A. & Lynch, L. Diet, nutrient supply, and tumor immune responses. Trends in Cancer, 9, 752–763 (2023) | PubMed

Harmon, Cathal.  Alexandra Zaborowski, Haim Moore, Pamela St. Louis, Karen Slattery, Danielle Duquette, John Scanlan,  Harry Kane, Britta Kunkemoeller, Claire L. McIntyre, Aine Ni Scannail, Bruce Moran, Ana C. Anderson, Des Winter, Donal Brennan, Michael A. Brehm & Lydia Lynch. γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors. Nature Cancer (2023) | PubMed

Douglas, A., Stevens, B. & Lynch, L. Interleukin-17 as a key player in neuroimmunometabolism. Nature Metabolism 5, 1088–1100 (2023) | PubMed

Dyck, L. & Lynch, L. Diverse effects of obesity on antitumor immunity and immunotherapy. Trends in Molecular Medicine 29, 112–123 (2023) | PubMed

Koay, H.-F. & Lynch, L. γδ T cells unveil invisible tumors. Trends in Immunology 44, 159–161 (2023) | PubMed

Kane, H., LaMarche, N. M.,  Ní Scannail, A.,  Garza, A. E., Koay, H. F., Azad, A. I., Kunkemoeller, B., Stevens, B., Brenner, M. B.,  Lynch, L. Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells. eLife 11, e76586 (2022) | PubMed

Zaborowski, A. M., Winter, D. C. & Lynch, L. The therapeutic and prognostic implications of immunobiology in colorectal cancer: a review. Br J Cancer 125, 1341–1349 (2021) | PubMed

Trim, W. V., & Lynch, L. (2022). Immune and non-immune functions of adipose tissue leukocytes. Nature reviews. Immunology, 22(6), 371–386. | https://pubmed.ncbi.nlm.nih.gov/34741167/

Prendeville, H., Lynch, L., 2022. Diet, lipids, and antitumor immunity. Cellular & Molecular Immunology, 19, pp. 432–444 | Pubmed

Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A.C., Fiala, G.J., Agudelo, L.Z., Dyck, L., Kane, H., Douglas, A., Cunningham, S., Prendeville, H., Loftus, R., Carmody, C., Pierre, P., Kellis, M., Brenner, M.B., Argüello, R.J., Silva-Santos, B., Pennington, D.J. and Lynch, L., 2021. Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nature Immunology, 22(2), pp.179-192. | PubMed

LaMarche, N.M., Kane, H., Kohlgruber, A.C., Dong, H., Lynch, L. and Brenner, M.B., 2020. Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis. Cell Metabolism, 32(2), pp.243-258. | PubMed

Kane, H. and Lynch, L., 2019. Innate immune control of adipose tissue homeostasis. Trends in immunology, 40(9), pp.857-872. | PubMed

Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38. | PubMed

Wu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641. | PubMed

Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner,David Finlay & Lynch, L. 2018. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology. | PubMed

Kohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1. | PubMed

Dyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity, 48(1), pp.9-11.  | PubMed

LaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism, 27(3), pp.485-486. | PubMed

Dyck, L. and Lynch, L., 2018. Cancer, obesity and immunometabolism–Connecting the dots. Cancer letters, 417, pp.11-20. | PubMed

SK. Chang, A. Kohlgruber, F. Mizoguchi, M. Xavier, B. Wolf, K. Wei, P. Lee, L. Lynch, D.Duquette, V.Ceperuelo-Mallafre, A. Banks, M.B. Brenner. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal of Clinical Investigation, in press Sept 2017. | PubMed

Prüss, H., Tedeschi, A., Thiriot, A., Lynch, L., Loughhead, S.M., Stutte, S., Mazo, I.B., Kopp, M.A., Brommer, B., Blex, C. and Geurtz, L.C., 2017. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nature neuroscience, 20(11), p.1549. | PubMed  

Assmann, N., O’Brien, K.L., Donnelly, R.P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R.M., Heinrich, P., Oefner, P.J., Lynch, L., Gardiner, C.M. and Dettmer, K., 2017. Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nature immunology, 18(11), p.1197. | PubMed

S. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. (2017) Immunity 21, 46:273-286. | PubMed

L. Lynch, A.E. Hogan, D. Duquette, C. Lester, A. Banks, K. LeClair, D. Cohen, A. Ghosh, B. Lu, M. Corrigan, D. Stevanovic, E. Maratos-Flier, D. Drucker, D. O’Shea, and M.B. Brenner. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metabolism, 2016; 24(3):510-519. | PubMed

A. Kohngruber, N. La Marche, and L. Lynch. Adipose Tissue at the nexus of immunometabolism. Seminars in Immunology. 2016: 28(5):431-440.| PubMed

L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology 2015;16(1):85-95. | PubMed

E. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed

A. Kohngruber, and L. Lynch. Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes. Current Diabetes Reports, 2015:15(11):92. | PubMed

A. Longchamp, M. Tao, A. Bartelt, K. Ding, L. Lynch, C. Hine, J. Corpataux, B.S. Kristal, J.R. Mitchell, and C.K. Ozaki. Surgical injury induces local and distant adipose tissue browning. Adipocyte, 2015;5(2):163-174. | PubMed

E.Y. Kim, L. Lynch, P.J. Brennan, N.R. Cohen, and M.B. Brenner. The transcriptional programs of iNKT cells. Review. Seminars in Immunology, 2015;27(1):26-32. | PubMed

M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. | PubMed

L. Lynch. Adipose invariant Natural Killer T cells. Review. Immunology, 2014;142(3):337-46. | PubMed

G.A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes 2014; 63(6):2037-50. | PubMed

A.E. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetalogica 2014; 57(4):781-4. | PubMed

L. Lynch, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Prodution. Immunity, 2012; 21;37(3):574-87. | PubMed

L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, L. Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. American J Reproductive Immunology 2012; 67(1):9-16. | PubMed

M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells Clin Immunol. 2011; 140(2):184-95. | PubMed

J. O’Connell, L. Lynch, A.E. Hogan, T.J. Cawood, and D. O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. Journal of Clinical Endocrinology and Metabolism, 2012; 96: 680-684. | PubMed

A.E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. Diabetalogica, 2011; 54(11):2745-2754. | PubMed

A.E. Hogan, M.A. Corrigan, V . O’Reilly, G. Gaoatswe, J. O’Connell, D.G. Doherty, L. Lynch, and D. O’Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol, 2011; 40(3):229-35. | PubMed

A.M. Tobin, L. Lynch, B. Kirby, and C. O’Farrelly. Natural killer cells in psoriasis. Review. J. Innate Immunity, 2011; 3(4):403-410. | PubMed

D. O’Shea, T.J. Cawood, C. O’Farrelly, and L. Lynch. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. 2010; 25;5(1):e8660. | PubMed

M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol, 2010; 40(3):682-687. | PubMed

J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One, 2010; e9997. | PubMed

A. O’Donovan, B.M. Hughes, G.M. Slavich, L. Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. Brain Behav Immun, 2010; 24(7):1074-7. | PubMed

L. Lynch, D. O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. Eur. J. Immunology, 32009; 9(7):1893-1901. | PubMed

L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? Obesity (Silver Spring) 2009; 17:601-605. | PubMed

E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility. American Journal of Reproduction, 2008; 61:265-276. | PubMed

L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? Human Reproduction, 2006; 22:919-26. | PubMed

L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. Journal of Immunology, 2006; 176: 5199-5204. | PubMed