Publications

Journal Articles
  1. Kohlgruber, A.C., Gal-Oz, S.T., LaMarche, N.M., Shimazaki, M., Duquette, D., Nguyen, H.N., Mina, A.I., Paras, T., Tavakkoli, A., Andrian, U., Banks, A.S., Shay, T., Brenner, M.B., Lynch, L. 2018. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature immunology, p.1.

  2. Dyck, L. and Lynch, L., 2018. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity48(1), pp.9-11.

  3. LaMarche, N.M. and Lynch, L., 2018. Adipose Dendritic Cells Come Out of Hiding. Cell metabolism27(3), pp.485-486.

  4. Dyck, L. and Lynch, L., 2018. Cancer, obesity and immunometabolism–Connecting the dots. Cancer letters417, pp.11-20.

  5. SK. Chang, A. Kohlgruber, F. Mizoguchi, M. Xavier, B. Wolf, K. Wei, P. Lee, L. Lynch, D.Duquette, V.Ceperuelo-Mallafre, A. Banks, M.B. Brenner. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal of Clinical Investigation, in press Sept 2017

  6. Prüss, H., Tedeschi, A., Thiriot, A., Lynch, L., Loughhead, S.M., Stutte, S., Mazo, I.B., Kopp, M.A., Brommer, B., Blex, C. and Geurtz, L.C., 2017. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nature neuroscience20(11), p.1549.

  7. Assmann, N., O’Brien, K.L., Donnelly, R.P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R.M., Heinrich, P., Oefner, P.J., Lynch, L., Gardiner, C.M. and Dettmer, K., 2017. Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nature immunology18(11), p.1197.

  8. S. Boulenouar , X. Michelet, D. Duquette, D. Alvarez , A.E. Hogan, C. Dold , D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M.A. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. (2017) Immunity 21, 46:273-286. PubMed

  9. L. Lynch, A.E. Hogan, D. Duquette, C. Lester, A. Banks, K. LeClair, D. Cohen, A. Ghosh, B. Lu, M. Corrigan, D. Stevanovic, E. Maratos-Flier, D. Drucker, D. O’Shea, and M.B. Brenner. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metabolism, 2016; 24(3):510-519. | PubMed

  10. A. Kohngruber, N. La Marche, and L. Lynch. Adipose Tissue at the nexus of immunometabolism. Seminars in Immunology. 2016: 28(5):431-440.| PubMed

  11. L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H.F. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology 2015;16(1):85-95. | PubMed

  12. E. Carolan, L.M. Tobin, B.A. Mangan, M.A. Corrigan, G. Gaoatswe, G. Byrne, J. Geoghegan, D. Cody, J. O’Connell, D.C. Winter, D.G. Doherty, L. Lynch, D. O’Shea, and A.E. Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, 2015;194(12):5775-5780. | PubMed

  13. A. Kohngruber, and L. Lynch. Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes. Current Diabetes Reports, 2015:15(11):92. | PubMed

  14. A. Longchamp, M. Tao, A. Bartelt, K. Ding, L. Lynch, C. Hine, J. Corpataux, B.S. Kristal, J.R. Mitchell, and C.K. Ozaki. Surgical injury induces local and distant adipose tissue browning. Adipocyte, 2015;5(2):163-174. | PubMed

  15. E.Y. Kim, L. Lynch, P.J. Brennan, N.R. Cohen, and M.B. Brenner. The transcriptional programs of iNKT cells. Review. Seminars in Immunology, 2015;27(1):26-32. | PubMed

  16. M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. | PubMed

  17. L. Lynch. Adipose invariant Natural Killer T cells. Review. Immunology, 2014;142(3):337-46. | PubMed

  18. G.A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes 2014; 63(6):2037-50. | PubMed

  19. A.E. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetalogica 2014; 57(4):781-4. | PubMed

  20. L. Lynch, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Prodution. Immunity, 2012; 21;37(3):574-87. | PubMed

  21. L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, L. Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. American J Reproductive Immunology 2012; 67(1):9-16. | PubMed

  22. M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells Clin Immunol. 2011; 140(2):184-95. | PubMed

  23. J. O’Connell, L. Lynch, A.E. Hogan, T.J. Cawood, and D. O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. Journal of Clinical Endocrinology and Metabolism, 2012; 96: 680-684. | PubMed

  24. A.E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. Diabetalogica, 2011; 54(11):2745-2754. | PubMed

  25. A.E. Hogan, M.A. Corrigan, V . O’Reilly, G. Gaoatswe, J. O’Connell, D.G. Doherty, L. Lynch, and D. O’Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol, 2011; 40(3):229-35. | PubMed

  26. A.M. Tobin, L. Lynch, B. Kirby, and C. O’Farrelly. Natural killer cells in psoriasis. Review. J. Innate Immunity, 2011; 3(4):403-410. | PubMed

  27. D. O’Shea, T.J. Cawood, C. O’Farrelly, and L. Lynch. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. 2010; 25;5(1):e8660. | PubMed

  28. M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol, 2010; 40(3):682-687. | PubMed

  29. J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One, 2010; e9997. | PubMed

  30. A. O’Donovan, B.M. Hughes, G.M. Slavich, L. Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. Brain Behav Immun, 2010; 24(7):1074-7. | PubMed

  31. L. Lynch, D. O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. Eur. J. Immunology, 32009; 9(7):1893-1901. | PubMed

  32. L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? Obesity (Silver Spring) 2009; 17:601-605. | PubMed

  33. E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility. American Journal of Reproduction, 2008; 61:265-276. | PubMed

  34. L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? Human Reproduction, 2006; 22:919-26. | PubMed

  35. L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. Journal of Immunology, 2006; 176: 5199-5204. | PubMed

Book Chapters
  1. M.A. Exley, L. Lynch, M. Nowak. NKT Cells of Cancer Patients and How Models Can Inform Therapeutic Plans (2012) [chapter]. In: Natural Killer T cells. Balancing the Regulation of Tumor Immunity. Terabe M, Berzofsky JA, editors.