Research

The Lynch Lab studies immunometabolism- how the immune and metabolic systems interact. Our research focuses on the role of innate immune cells in regulating systemic metabolism, and coming full circle to the effects of altered metabolism on immune cell function. Thus, we study immunometabolism at both the organismal and cell-intrinsic level, which is at an exciting time of convergence. We use obesity and diabetes as well as the tumor microenvironment as models to show how the nutrient supply or diet can influence immune cell functions through altering their cellular metabolism. We use state of the art techniques including imaging comprehensive whole body analysis to study immunometabolic interactions in vivo. Save

Convergence of Systemic and Cellular Immunometabolism

/
Lean adipose tissue is characterized by an enrichment of…

Innate immune cells in adipose tissue

/
The immune system in adipose tissue is largely under-appreciated,…

Adipose iNKT cells

/
Obesity has reached epidemic proportions globally. At least 2.8…

γδ T cells

/
The lab studies γδ T cells in humans and mice, and the transcriptional…

NK Cells

/
One key aspect of our research is to understand the effects of…